The Vikings and 49ers were tallied at the start of the season, but came down to 0.500 and recorded two back-to-back winning streaks in Week 12. Minnesota has a good chance of winning as NFL betting underdog – find out why with our choices.
It’s been a good few weeks for the Vikings and 49ers. The 49ers beat the Rams and Jags, while the Vikings beat the Packers and Chargers, with both teams getting into the playoff conversation.
If you are betting on this game, you will need our NFL picks and predictions for the Minnesota Vikings vs San Francisco 49ers.
Vikings vs 49ers odds
Odds via the Covers Line, an average made up of the odds of several sports bets.
Since the lines opened, we’ve seen the 49ers go from 2.5 point favorites to 3 point favorites. We also saw the point total drop from 48 to 49. Use the live odds widget above to track future line moves until kickoff and be sure to check out the full NFL odds. before placing your bets.
Vikings vs 49ers predictions
Predictions made on 11/25/2021 at 11:00 a.m.ET.
Click on each prediction to access the full analysis.
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Vikings vs 49ers match information
• Site: Levi’s Stadium, Santa Clara, California
• Dated: Sunday November 28, 2021
• Time: 4:25 p.m. ET
• TV: FOX
Vikings at 49ers betting overview
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Vikings: Wyatt Davis G (Questionable), Michael Pierce DT (Released), Everson Griffen DE (Released), Irv Smith TE (Released).
49ers: Maurice Hurst DL (Released), Tavon Wilson S (Released), Mike McGlinchey T (Released), Javon Kinlaw (Released), Jason Verrett CB (Released), Raheem Mostert RB (Released).
Find our latest NFL injury reports.
Betting trend to know
The Vikings are 4-0 ATS in their last four road games. Check out other NFL betting trends for the Vikings vs 49ers.
Picks and predictions Vikings vs 49ers
Our predictions are compiled from the spread and total analysis and are indications of where we are looking for this match.
Our best bet is the game we love the most for that game, which we would actually put some of our bankroll into.
Both teams are 5-5 and enter this game with back-to-back winning streaks. The 49ers knocked out the Jacksonville Jaguars last Sunday after a very impressive victory over the Rams a week earlier. Meanwhile, the Vikings beat the Packers to death last week, after beating the Chargers a week earlier.
The Vikings have been a difficult team to understand this season. All of their games except one ended with the Vikings one point away from the other team, for better or for worse. They’ve also had a pretty tough schedule along the way, which makes their 5-5 record all the more impressive. There is no doubt in my mind that the Vikings are the best team in the NFL with no records, even ahead of their rivals on Sunday.
Beating rivals NFC North is never easy, but the Vikings pulled it out of the bag against the Packers last week. They only won the game in the dying seconds, but it was a good performance. Kirk Cousins threw for 341 yards, including 169 for Justin Jefferson, the second hitting his eight targets for two touchdowns. Dalvin Cook scolded for 86 yards and a touchdown and got the Packers in trouble on the ground.
Kyle Shanahan’s offense has also hit form, scoring 111 points in their last four games, averaging a staggering 27.75 points per game. Jimmy Garoppolo is always in the middle and struggled at times, with a badly thrown pass to Jeff Wilson against the Jaguars, a real indictment against his abilities. Regardless of that, he’s still this team’s flagman, but he’s not the real star – he’s Kyle Shanahan. He turned the talented Deebo Samuel into a utility tool that is a star of this Niners attack. It ranks number one in forced missed tackles per stroke (25+ races) since 2019, per PFF, and has really broken out this year.
So here we have two fairly well-matched teams, both similar in defensive capacity, with identical records and capable of great moments in attack. When it comes to choosing a side, we have to look at which Vikings to cover. They have a strange ability to stay away from those they face and the 49ers aren’t clinical enough. I’m happy to take the Vikings on the silver line so getting the extra 3 points on the spread is a real blessing.
Prediction: Vikings +3.0 (+100)
Covers NFL betting analysis
Over / Under Analysis
Neither team has an elite defense, despite recent reputations. The Niners are ranked 12th in weighted defensive DVOA, two spots ahead of the Vikings, and both teams have given their opponents opportunities in recent weeks. This leads me to think that these two dynamic attacks will be free to score points and end up in another shootout for the Vikings.
Considering their habit of going into high-scoring games, it’s no surprise that the Over is 6-1 in the Vikings’ last seven road games. The trends also point us towards the Over for the 49ers, with the Over 6-1 in their last seven games after a win against ATS. We will follow the trends and support this game to become another high scoring shootout, which should easily exceed 49 points total.
Prediction: Over 49 (-110)
Remember when the season started and second-year wide receiver Brandon Aiyuk didn’t have a lot of playing time? All the wheelchair pundits on social media were pissed off and the fantasy managers were pissed off that their broad draft wasn’t doing much. Now it’s safe to say that the tide has turned and Aiyuk has had its day in Kyle Shanahan’s doghouse.
Samuel has rightly been the big story for this 49ers team, but Aiyuk has really caught on in the past month. In his last four games, Aiyuk has had target shares of 25.9, 20.5, 21.1 and 36.8%. That leads into Sunday’s game, where sports betting set the line on Aiyuk’s receptions at 4.5. That’s a number we’re going to hit the Over on all day.
In the last three games, Aiyuk has seen 19 targets, 16 receptions, 200 yards and two touchdowns. When a player goes up like this, you have to support him to continue that form. It’s worth considering Aiyuk for other prop markets, including all-time touchdown scorers and receiving yards, but I think it’s that prop, the total receptions, that gives us the best opportunity to win and at +130 it is also a very good price.
To take: Brandon Aiyuk Over 4.5 receptions (+130)